Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability
نویسندگان
چکیده
منابع مشابه
Cell-cycle regulation of formin-mediated actin cable assembly.
Assembly of appropriately oriented actin cables nucleated by formin proteins is necessary for many biological processes in diverse eukaryotes. However, compared with knowledge of how nucleation of dendritic actin filament arrays by the actin-related protein-2/3 complex is regulated, the in vivo regulatory mechanisms for actin cable formation are less clear. To gain insights into mechanisms for ...
متن کاملDeconstructing formin-dependent actin cable assembly.
Eukaryotic cells are organized in three dimensions to allow for both cell division and for them to perform their physiological functions. This organization is dependent upon the arrangement of the cytoskeleton, which can either generate force by subunit polymerization or serve as tracks for molecular motors to deliver protein complexes, RNAs, or membrane-bound compartments. In general, long-ran...
متن کاملDirecting exocrine secretory vesicles to the apical membrane by actin cables generated by the formin mDia1.
The final stage in exocrine secretion involves translocation of vesicles from their storage areas to the apical membrane. We show that actin-coated secretory vesicles of the exocrine pancreas travel this distance over bundles of specialized actin cables emanating from the apical plasma membrane. These bundles are stable structures that require constant G-actin incorporation and are distinct fro...
متن کاملDynamics of the Formin For3p in Actin Cable Assembly
BACKGROUND Formins are a conserved family of actin nucleators responsible for the assembly of diverse actin structures such as cytokinetic rings and filopodia. In the fission yeast Schizosaccharomyces pombe, the formin for3p is necessary for the formation of actin cables, which are bundles of short parallel actin filaments that regulate cell polarity. These filaments are largely organized with ...
متن کاملThe F-BAR protein Hof1 tunes formin activity to sculpt actin cables during polarized growth
Asymmetric cell growth and division rely on polarized actin cytoskeleton remodeling events, the regulation of which is poorly understood. In budding yeast, formins stimulate the assembly of an organized network of actin cables that direct polarized secretion. Here we show that the Fer/Cip4 homology-Bin amphiphysin Rvs protein Hof1, which has known roles in cytokinesis, also functions during pol...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2020
ISSN: 1465-7392,1476-4679
DOI: 10.1038/s41556-020-0524-x